SCIENTIFIC PAPERS

Decoupling Individual Host Response and Immune Cell Engager Cytotoxic Potency. Gonzàlez Gutierrez C, Aimard A, Biarnes-Pélicot M, Kerfelec B, Puech PH, Robert P, Piazza F, Chames P, Limozin L. ACS Nano. 2025 Jan 21;19(2):2089-2098. doi: 10.1021/acsnano.4c08541.

Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off‐rates. Johannes Pettmann, Lama Awada, Bartosz Różycki , Anna Huhn, Sara Faour, Mikhail Kutuzov, Laurent Limozin, Thomas R. Weikl, P. Anton van der Merwe*, Philippe Robert *†( † : co-dernier auteur), and Omer Dushek *† EMBO Journal 2023, doi : 10.15252/embj.2022111841 PMID : 36484367.-commented in EMBO J . 2023 Apr 3;42(7):e113507. doi: 10.15252/embj.2023113507. Epub 2023 Feb 20.

Immune thrombotic thrombocytopenic purpura plasmas induce calcium- and IgG-dependent endothelial activations: correlations with disease severity. Edwige Tellier, Agnès Widemann, Raphaël Cauchois, Julien Faccini, Marie Lagarde, Marion Brun , Philippe Robert, Stéphane Robert, Richard Bachelier, Pascale Poullin Elien Roose, Karen Vanhoorelbeke, Paul Coppo, Françoise Dignat-George, Gilles Kaplanski Haematologica 2022 PMID: 36453103 DOI: 10.3324/haematol.2022.280651

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment. Robert P*, Limozin L*, van der Merwe PA*, Bongrand P*. Cells. 2021 Feb 18;10(2):429. doi: 10.3390/cells10020429. PMID: 33670573

Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rates. Gaïa Zirka, Philippe Robert, Julia Tilburg , Victoria Tishkova, Chrissta X Maracle, Paulette Legendre, Bart J M van Vlijmen, Marie-Christine Alessi, Peter J Lenting, Pierre-Emmanuel Morange, Grace M Thomas* Blood. 2021 Apr 22;137(16):2256-2266. doi: 10.1182/blood.2020008345. -commented in Blood, doi: 10.1182/blood.2021010838. PMID: 33885707 -cover image for Blood, 137(16)

Functional Mapping of Adhesiveness on Live Cells Reveals How Guidance Phenotypes Can Emerge From Complex Spatiotemporal Integrin Regulation. Robert P*, Biarnes-Pelicot M, Garcia-Seyda N, Hatoum P, Touchard D, Brustlein S, Nicolas P, Malissen B, Valignat MP, Theodoly O*. Front Bioeng Biotechnol. 2021 Apr 7;9:625366. doi: 10.3389/fbioe.2021.625366. eCollection 2021.PMID: 33898401

Three-dimensional imaging with reflection synthetic confocal microscopy. Rasedujjaman M, Affannoukoué K, Garcia-Seyda N, Robert P, Giovannini H, Chaumet PC, Theodoly O, Valignat MP, Belkebir K, Sentenac A, Maire G *. Opt Lett. 2020 Jul 1;45(13):3721-3724. doi: 10.1364/OL.397364.PMID: 32630938

TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding. Limozin L, Bridge M, Bongrand P, Dushek O, van der Merwe PA, Robert P*. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16943-16948. doi: 10.1073/pnas.1902141116. Epub 2019 Jul 17.PMID: 31315981 –commented in PNAS, doi: 10.1073/pnas.1911389116. PMID: 31371492

Nanobody-CD16 Catch Bond Reveals NK Cell Mechanosensitivity. González C, Chames P, Kerfelec B, Baty D, Robert P*, Limozin L*. Biophys J. 2019 Apr 23;116(8):1516-1526. doi: 10.1016/j.bpj.2019.03.012. Epub 2019 Mar 23.

A Rough Energy Landscape to Describe Surface-Linked Antibody and Antigen Bond Formation. Limozin L, Bongrand P, Robert P*. Sci Rep. 2016 Oct 12;6:35193. doi: 10.1038/srep35193.PMID: 27731375

The leukocyte-stiffening property of plasma in early acute respiratory distress syndrome (ARDS) revealed by a microfluidic single-cell study: the role of cytokines and protection with antibodies. Preira P, Forel JM, Robert P, Nègre P, Biarnes-Pelicot M, Xeridat F, Bongrand P, Papazian L, Theodoly O*. Crit Care. 2016 Jan 12;20:8. doi: 10.1186/s13054-015-1157-5.PMID: 26757701

Leishmania infection modulates beta-1 integrin activation and alters the kinetics of monocyte spreading over fibronectin. Figueira CP, Carvalhal DG, Almeida RA, Hermida Md, Touchard D, Robert P, Pierres A, Bongrand P, dos-Santos WL*. Sci Rep. 2015 Aug 7;5:12862. doi:.1038/srep12862.PMID: 26249106

Biophysical description of multiple events contributing blood leukocyte arrest on endothelium. Robert P, Touchard D, Bongrand P*, Pierres A. Front Immunol. 2013 May 15;4:108. doi: 10.3389/fimmu.2013.00108. eCollection 2013.PMID: 23750158 (review)

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands. Robert P, Aleksic M, Dushek O, Cerundolo V, Bongrand P*, van der Merwe PA. Biophys J. 2012 Jan 18;102(2):248-57. doi: 10.1016/j.bpj.2011.11.4018.PMID: 22339861

Quantitative modeling assesses the contribution of bond strengthening, rebinding and force sharing to the avidity of biomolecule interactions. Lo Schiavo V, Robert P, Limozin L, Bongrand P*. PLoS One. 2012;7(9):e44070. doi: 10.1371/journal.pone.0044070. Epub 2012 Sep 14.PMID: 23024747

Total serum tryptase levels are higher in young infants. Belhocine W, Ibrahim Z, Grandné V, Buffat C, Robert P, Gras D, Cleach I, Bongrand P, Carayon P, Vitte J*. Pediatr Allergy Immunol. 2011 Sep;22(6):600-7. doi: 10.1111/j.1399-3038.2011.01166.x. Epub 2011 Jul 8.PMID: 21736626

Minimal encounter time and separation determine ligand-receptor binding in cell adhesion. Robert P, Nicolas A, Aranda-Espinoza S, Bongrand P, Limozin L*. Biophys J. 2011 Jun 8;100(11):2642-51. doi: 10.1016/j.bpj.2011.04.011.PMID: 21641309

A novel leukocyte adhesion deficiency III variant: kindlin-3 deficiency results in integrin- and nonintegrin-related defects in different steps of leukocyte adhesion. Robert P, Canault M, Farnarier C, Nurden A, Grosdidier C, Barlogis V, Bongrand P, Pierres A, Chambost H, Alessi MC*. J Immunol. 2011 May 1;186(9):5273-83. doi: 10.4049/jimmunol.1003141. Epub 2011 Mar 25.PMID: 21441448

Immune profile of elderly patients admitted in a geriatric short care unit. Crétel E, Veen I, Pierres A, Binan Y, Robert P, Loundou AD, Baumstarck-Barrau K, Hubert AM, Bongrand P*, Heim M*. Rev Med Interne. 2011 May;32(5):275-82. doi: 10.1016/j.revmed.2010.10.002. Epub 2010 Nov 26.PMID: 21112131 French.

Jet exhaust particles alter human dendritic cell maturation. Ferry D, Rolland C, Delhaye D, Barlesi F, Robert P, Bongrand P, Vitte *J. Inflamm Res. 2011 Mar;60(3):255-63. doi: 10.1007/s00011-010-0262-9. Epub 2010 Oct 12.PMID: 20938710

Force measurements of TCR/pMHC recognition at T cell surface. Puech PH, Nevoltris D, Robert P, Limozin L, Boyer C, Bongrand P*. PLoS One. 2011;6(7):e22344. doi: 10.1371/journal.pone.0022344. Epub 2011 Jul 22.PMID: 21799834

Fish allergy: in Cyp c1 we trust. Agabriel C, Robert P, Bongrand P, Sarles J, Vitte J*. Allergy. 2010 Nov;65(11):1483-4. doi: 10.1111/j.1398-9995.2010.02351.x.PMID: 20337612

Local and systemic activation of the mononuclear phagocyte system in aseptic loosening of total hip arthroplasty. Flecher X, Rolland C, Rixrath E, Argenson JN, Robert P, Bongrand P, Wendling S, Vitte J*. J Clin Immunol. 2009 Sep;29(5):681-90. doi: 10.1007/s10875-009-9305-9. Epub 2009 Jun 18.PMID: 19536644

Biomolecule association rates do not provide a complete description of bond formation. Robert P, Limozin L, Pierres A, Bongrand P*. Biophys J. 2009 Jun 3;96(11):4642-50. doi: 10.1016/j.bpj.2009.03.020.PMID:

Tuning the formation and rupture of single ligand-receptor bonds by hyaluronan-induced repulsion. Robert P, Sengupta K, Puech PH, Bongrand P, Limozin L*. Biophys J. 2008 Oct;95(8):3999-4012. doi: 10.1529/biophysj.108.135947. Epub 2008 Jul 3.PMID: 18599637

What is the relevance of the specific bond properties revealed by single-molecule studies? Robert P, Benoliel AM, Pierres A, Bongrand P*. J Mol Recognition. 2007 Nov-Dec20(6):432-47. Doi: 10.1002/jmr.827 (review)