CR1 Inserm, HDR, PhD
Mail : pierre-henri.puech@inserm.fr
Education and positions
* Since 2005 : Researcher (CR1 Inserm since 2009) in Inserm U1067 (Adhesion & Inflammation, Marseille, France), Habilitation / HDR (2009) ; head : Pr. P. Bongrand, now O. Théodoly
* Dec. 2003 – dec. 2005 : post doc in Prof. D. J. Muller’s Group (Dresden, Allemagne) – labs : Biotec, TU-Dresden & Max Planck for Cell Biology and Genetics. Developing single cell force spectroscopy with AFM. Application to cell /cell recognnition in immunology, cancer cell biology and development (collab. CP Heinseberg).
* Oct. 2000 – Oct. 2003 : PhD in Biophysics (Univ. Paris VI) in Prof. F. Brochard-Wyart lab : UMR 168 CNRS / Institut Curie (Paris, France). Adhesion and mecanics of giant liposomes (collab. PG de Gennes).
* Oct. 2000 : Engineer from the Ecole Superieure de Physique et de Chimie Industrielle de la ville de Paris (ESPCI, Paris, France )
* Oct. 1999 – June 2000 : Master in Soft Condensed Matter with highest honors (Univ. Paris VI). Adhesion of parasite fungi. Adhesion and rolling of sticky polymeric beads.
Member of Institut Covergence CenTuri, Labex INFORM, SBCF, GDR CellTiss, GDR MecaBio
Research expertise
Soft condensed matter. Biophysics
Biology, especially : cell adhesion and mechanics. Immunology. Cell biology. Developmental biology.
Force measurements on single molecules or single cells using micropipette, biomembrane force probe (BFP) or atomic force microscopy (AFM) -based techniques. Optical microscopy (fluorescence). AFM Imaging
Programming (Labview, IgorPro, Python, R)
Current research interests
(1) T cell recognition, mechanics and signalling (collaborations Dr. L Limozin & P Robert, Inserm U1067, Marseille ; Dr. Y. Hamon, Dr HT He, CIML, Marseille ; K. Sengupta, CINaM, Marseille, Dr. J Husson, LaDHyX Paris, Dr. P. Pierobon, Institut Curie, Paris)
(2) Toxoplasma mechanics and adhesion (collaboration Dr. A Dumètre, Pharmacy Univ, Marseille)
(3) Adhesion and mechanics in cancer (collaboration Prof. L Counillon, TIANP, Nice & Dr. A. Badache, CRCM, Marseille)
(4) Mechanobiology of fibrosis (collaboration with Pr. M. Hautefeuille, UNAM, Mexico-city, Mexico)
Received grants
National : Inserm PhysCancer « H+cancer » 2012 ; ANR JCJC « DissecTion» 2009 (coordinator) ; CNRS Prise de risques 2007 ; ANR JCJC « Adhekon » 2006
International : Human Frontier Science Program (Short term) 2007 (coordinator)
Function in the lab
Responsible for AFM, optical tweezers and micromanipulation/BFP set tups
Responsible for communication (Inserm, CNRS)
Responsible for informatics (Inserm)
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