We’re thrilled to announce LAI’s 30th Anniversary Symposium, taking place on October 3rd and 4th at the Hexagon Auditorium in Luminy!

This special event will feature a lineup of speakers sharing their research and insights covering the various topics of the lab. It’s a unique opportunity to celebrate 30 years of research and reflect on our collective achievements. We are excited to welcome alumni, collaborators, associates of the lab, and the scientific community, who have all played a part in our journey.

The registration is free but mandatory, so be sure to reserve your spot here: https://lai30.sciencesconf.org/

For the full program schedule, please visit: https://labadhesioninflammation.org/30years/

We can’t wait to see you there for this milestone event!

We are excited to share Arnauld Sergé‘s participation in European Thymus in Porto, 27-31 May 2024

Arnauld presented a poster titled “Dynamics and Blockade of RANK/RANKL Interactions Between Leukemic and Thymic Epithelial Cells,” with contributions from Loriane Maillot, Martine Biarnes Pelicot, and Magali Irla from CIML.

T-cell acute lymphoblastic leukemias (T-ALL) are aggressive hematological cancers arising in the thymus from the malignant transformation of thymocytes. RANK and its ligand RANKL play a key role in thymic crosstalk. RANKL promotes thymic epithelial cell differentiation, sustaining the generation of a self-tolerant T-cell repertoire. The RANK/RANKL axis is a therapeutic target in oncology. However, its role in T-ALL remains unclear. RANKL is overexpressed during leukemogenesis. (i) we evaluate the dynamics of RANK/RANKL interactions, measured by single-molecule tracking. We evaluate the effects of an anti-RANKL antibody, a decoy receptor and the soluble form of RANKL. (ii) we assessthe therapeutic potential of an anti-RANKL antibody in T-ALL dissemination. Our aim is to shed light on the role of the RANK/RANKL axis in the emergence and dissemination of T-ALL.

We are excited to present our team’s key contributions to the GDR Approches Quantitatives du Vivant 2024 conference, held in Vogüé, Ardèche:

• Ahmad Awada’s Poster Presentation: “Amoeboid Swimming is Propelled by Molecular Paddling in Lymphocytes”
• Jana El Husseiny’s Poster Presentation: “Unraveling Morphological and Biomechanical Responses to Harsh Environmental Conditions in Coccidian Oocysts”
• Valentine Seveau de Noray’s Talk: “Reverse Adhesive Haptotaxis: Cell Migration Towards Low Adhesion”

We extend our gratitude to the conference organizers for a stimulating and inspiring event. We look forward to continuing our research and sharing our findings with the scientific community.

After a successful virtual conference in 2021, LAI members Pierre-Henri Peuch and Laurent Limozin took on the challenge of re-organizing the EMBO Workshop on ImmunoBiophysics: From fundamental physics to understanding the immune response. This time, the attendees had the chance to gather in the heart of Haute-Savoie at the Les Houches Physics School!

In addition, our Ph.D. students Marie Dessard, Jana El Husseiny, and Lama Awada presented posters on their projects while Rémy Torro gave a contributed talk for which he won the best talk prize!

For more information and updates on the upcoming organized talks: https://meetings.embo.org/event/23-immunobiophysics

The EMBO Workshop: ImmunoBiophysics: From fundamental physics to understanding immune response is back with its newest edition! The workshop which is organized by our very own Pierre-Henri Puech and Laurent Limozin boasts an impressive list of speakers in the life sciences, biophysics, and mechanobiology fields.

The registration deadline is 5 March 2023. For more information: https://meetings.embo.org/event/20-immunobiophysics

Beatriz Díaz Bello and Rémy Torro participated at the New Microscopies in Cell Biology at Institut Jacques Monod in Paris where they co-presented a talk entitled “A deep learning-based software to measure immune cytotoxicity, in single cells, over time”, a co-presentation that highlights the interdisciplinary pursued at LAI and the constant back and forth between biologists and physicists. The conference was co-organized by Pierre-Henri Puech.

For more information: https://newmic4cellbio.sciencesconf.org/ on December 13th

Flash talk – DIAZ BELLO Beatriz (LAI): A deep learning-based modular software to locate, track and measure single-cell ADCC over time.

Flash talk – NUÑEZ VIADERO EIDER (LAI): Development of the state of the art technology to monitor protein-folding in real time under physiological conditions.

Flash talk – ROBERT Philippe (LAI): On and off-rates measurements at the single molecular level with laminar flow chamber: a need for new links and linkers.