Welcome back Andrzej & Natalia!

We are pleased to have hosted Andrzej Kubiak and Natalia Bryniarska-Kubiak, a visiting post-doc from Jagiellonian University, Krakow, Poland. They have been in the lab for the past two months continuing their collaboration with Pierre-Henri Puech.

Natalia investigated mechanical interactions between stem cells and their microenvironment. She used traction force microscopy on soft PAA hydrogels and atomic force microscopy for the characterization of cell mechanics.

Andrzej’s research, titled “The role of mechanical interactions in the chondrogenic differentiation of stromal cells,” investigated the mechanobiology of chondrogenic differentiation of bone marrow stromal cells-derived spheroids combining AFM and TFM.

We wish them continued success in their future endeavors!

LAI Participates in Fête de la Science 2024!

We are excited to share that our lab took part in Fête de la Science on October 13th, 2024. This fantastic festival, celebrated across France, is dedicated to bringing science closer to the public, sparking curiosity, and inspiring everyone in the event.

LAI hosted a range of interactive stands covering diverse scientific disciplines, from biology to physics. It was a day full of learning, experimentation, and inspiration, where participants of all ages had the chance to dive into the fascinating world of science. We were thrilled to see so many curious minds visit our stands and actively engage with the experiments we prepared!

Thank you to everyone who joined us in celebrating the wonders of science!

Celebrating Our Lab’s 30 Years Anniversary!

This October, our lab marked a major milestone with a two-day symposium at the Hexagon Auditorium in Luminy. The event brought together distinguished speakers, alumni, collaborators, and the scientific community to reflect on 30 years of innovation and progress. Attendees enjoyed insightful presentations covering our lab’s research areas and celebrated the collaborative spirit driving our work forward.

A heartfelt thank you to everyone who joined us in commemorating this journey of scientific discovery! For more information and details about the event, please visit our page: https://labadhesioninflammation.org/30years/.

Physics of Living Matter 18 Conference Participation

We are excited to announce that several members of our laboratory participated in the 18th edition of the Physics of Living Matter Conference (PLM 18), held on September 16-17, 2024, at the Palais du Pharo, Marseille. This prestigious international symposium, organized by CENTURI – Turing Centre for Living Systems, gathered interdisciplinary scientists from all over the world to explore the interface between physics and biology.

Laurent Limozin, Florian Dupuy, Arnauld Serge, Gaurav Verma, Jana Elhusseiny, Ahmad Awada, and Lorna Ammer attended the event. During the poster sessions, Arnauld, Ahmad, Jana, and Gaurav presented their research through poster presentations.

The conference featured a vibrant environment for scientific exchange and collaboration. We are thrilled to have been a part of this inspiring event and look forward to contributing to future editions.

Laboratoire d’Informatique et Systèmes PhD Students Day !

We are pleased to share that Chandrasekar Subramani Narayana recently participated in the LIS (Laboratoire d’Informatique et Systèmes) PhD Students Day on June 7, 2024. He presented his work titled “Counting Phage: Decoding Antibody & Antigen Kinetics Behavior,” which focuses on the counting task in fluorescence microscopy images and count-guided localization using deep learning and computer vision.

The event offered a valuable opportunity for sharing scientific interests and knowledge while discovering the diverse range of topics being explored by other PhD students and research teams.

17th International Toxoplasmosis Conference Participation

We are excited to announce that Aurélien Dumètre and Jana El Husseiny recently attended the 17th International Toxoplasmosis Conference in Berlin, Germany. This event covered various aspects of Toxoplasma research, ranging from molecular biology to clinical disease and epidemiology.

Before the main conference, they participated in the 3rd Environmental Toxoplasmosis Meeting, co-organized by Aurélien Dumètre and other experts in the field. This meeting focused on advancing the understanding of the environmental aspects and public health implications of Toxoplasmosis. Additionally, they attended a joint session with the ToxoDB workshop, which aimed to enhance participants skills and knowledge in using the ToxoDB database for research and data analysis.

Aurélien gave a talk at the workshop titled “Eimeria acervulina, a Promising Surrogate for the Study of Toxoplasma gondii Oocyst Inactivation.” Jana showcased her PhD project at both the workshop and the conference, delivering a talk at the workshop and presenting a turbo talk and a poster on her research titled “Unraveling Morphological and Biomechanical Responses to Harsh Environmental Conditions in Coccidian Oocysts.”

We are proud of their contributions and the recognition of their work at these significant scientific gatherings.

CENTURI – Turing Centre for Living Systems Scientific Day !

We are pleased to share that Ahmad Awada delivered an insightful presentation titled “Effects of Adhesion and Confinement on Leukocyte Migration” at the CENTURI – Turing Centre for Living Systems scientific day: Success Stories and New Horizons, held on May 30th at Jardins du Pharo.

The event was a remarkable gathering, bolstering the community spirit through networking and the sharing of ideas and future outlooks. It provided an excellent platform for researchers to connect, collaborate, and envision new horizons in scientific research.

LAI celebrated its newest Dr

On the 4th of April 2024, Rémy Torro, Ph.D. successfully defended his work titled “High throughput analysis of dynamic single cell interactions imaged by multimodal optical microscopy” in front of a jury composed of experts in the field, Alice Nicolas, David Rousseau, Daniel Sage, Loïc Dupré under the supervision of Laurent Limozin and Kheya sengupta. His work focused on develloping a software called Celldetective to describe complex cell interactions from multimodal microscopy images, leveraging recent AI techniques and applying it to test cell engagers for immunotherapy in cell-surface and cell-cell interaction assays.

Celldetective is now available and free to use on GitHub: https://lnkd.in/dGpj_UUx

Best of luck, Remy!

remy'defense

In association with CENTURI – Turing Centre for Living Systems

A new article on AI Tools for Immunofluorescence-Based Diagnostics

We are excited to share our latest research published in the International Journal of Molecular Sciences: “Comparison of the Capacity of Several Machine Learning Tools to Assist Immunofluorescence-Based Detection of Anti-Neutrophil Cytoplasmic Antibodies.”

This work was conducted in collaboration with Daniel Bertin and Nathalie Bardin, both members of the Immunology Laboratory of Marseille Hospitals, and Pierre Bongrand from LAI.

This study addresses a current challenge of using artificial intelligence to perform biomedical tasks without any human intervention, which might result in lower cost, increased availability and increased rapidity. Here, we compared the capacity of several widely available machine learning tools to analyze microscopic images in order to diagnose some autoimmunity diseases. The paper described preliminary results obtained with a dataset of 1,733 cell images.

For more information, visit the publication: https://doi.org/10.3390/ijms25063270.