The group of Tam Mignot, with which O. Theodoly has been collaborating for 10 years, is pursuing his leading research activity on the mechanisms of micro-organisms motility. A novel paper in the journal Nature with association of LAI for technical support on microscopy experiments has just been published: “The mechanism of force transmission at bacterial focal adhesion complexes”, Volume: 539, Issue: 7630, Pages: 530, DOI: 10.1038/nature20121, Published: NOV 24 2016.
Laura Faure, Jean Bernard Fiche, Leon Espinosa, Adrien Ducret, Jennifer Luciano, Sébastien Lhospice, Salim Islam, Julie Tréguier, Erkin Kuru, Yves Brun, Olivier Théodoly, Marcelo Nollmann, Tâm Mignot (2016) The mechanism of force transmission at bacterial focal adhesion complexes. Nature. 539(7630):530-535.
We published the first paper obtained with our in-house designed and built laminar flow chamber automation. This innovative machine allows fast single molecular force studies, for both kinetics and thermodynamic studies. Please see: A Rough Energy Landscape to Describe Surface-Linked Antibody and Antigen Bond Formation. Sci Rep. 2016 Oct 12;6:35193.
A Rough Energy Landscape to Describe Surface-Linked Antibody and Antigen Bond Formation. Limozin L, Bongrand P , Robert P (2016) Sci. Rep. 6:35193
Freppel W, Puech PH, Ferguson DJP, Azas N, Dubey JP, Dumètre A (2016) Macrophages facilitate the excystation and differentiation of Toxoplasma gondii sporozoites into tachyzoites following oocyst internalisation. Sci Rep. 2016 Sep 19;6:33654
Huerre A, Jullien MC, Theodoly O, Valignat MP (2016) Absolute 3D reconstruction of thin films topography in microfluidic channels by interference reflection microscopy. Lab. Chip. 16:911-916, doi 10.1039/C5LC01417D
Guillou L, Babataheri A, Puech PH, Barakat AI, Husson J (2016) Dynamic monitoring of cell mechanical properties using profile microindentation. Sci. Reports 6:21529.
Dillard P, Pi F, Lellouch AC, Limozin L, Sengupta K (2016) Nano-clustering of ligands on surrogate antigen presenting cells modulates T cell membrane adhesion and organization. Integrative Biology 8:287.
Preira P, Forel J-M, Robert P, Nègre, Biarnes M, Xeridat F, Bongrand P , Papazian L, Théodoly O (2016) The leukocyte stiffening property of plasma in acute respiratory distress syndrome (ARDS) revealed by microfluidic single-cell study: role of cytokines and protection with antibodies. Critical Care 20 : 8.
Bertin D, Mouhajir Y, Bongrand P, Bardin N (2016) ICARE improves antinuclear antibody detection by overcoming the barriers preventing accreditation. Clinica Chimica Acta 454 : 57-61.
Adhesion & Inflammation Lab 
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