Prof. Francesco Piazza “Conformation-controlled binding kinetics of antibodies” TPR2 Inserm
External seminar: Gerhardt Schütz
Prof. Gerhardt Schütz “Sensing single molecular forces in the immunological synapse” (coorganized with CINAM) TPR2 Inserm
New equipments on the cell culture platform of the INSERM TPR2 building (U1067-U1072-U1090-U1097)
Thanks to the co-financing of S. Spicuglia (U1090) and a mutual request of the units to the region (U1067-U1090-U1097), the common cell culture platform of the building has recently acquired:
- a sorter BD FACSMelody: 3 lasers, 9 colors and single-cell module
- a BD LSRFortessa X20 cell analyser : 3 lasers, 14 colors
Warm congratulations to Xuan Luo who became French Doctor
Xuan graduated after many years of happiness in France and at LAI. She’s heading back to China with a new job in Shanghai, but as an employee of a French company, she will have the chance to visit us in Marseille from time to time,
Congratuations for all the nice work and best wishes !
External seminar: Daniel Hammer
Prof. Daniel Hammer “Migration of ameboid cells: force, dynamics and memory” TPR2 Inserm
LAI welcomes new Research Engineer Lorenzo Villanueva!
Lorenzo Villanueva joined the lab in March 2019 and he will work under supervision of Felix Rico on developing LabVIEW software as interface for High Speed AFM. Welcome Lorenzo!
External seminar: Charlie Gosse
Dr. Charlie Gosse “A molecular DNA scaffold to characterize the dynamics of protein-protein interactions” TPR2 Inserm
A new article on T cells response to substrate elasticity in PNAS
Researchers from LAI and CINAM have joined their efforts to study how T-lymphocytes sense the mechanics of their underlying substrate in vitro, an important but poorly understood question. Using a wide range of stiffnesses for substrates covered with antibodies against T-Cell receptors, they observed that T-cell spread more on increasingly stiff substrates, until a maximal stiffness, where they start to spread less. This is reconciling apparent contradictory results from the literature. It was also observed that involvement of integrins in this process reestablish a monotonous response, as observed for non-immune cells. The observations are rationalized in terms of a simple quantitative clutch model which will be further tested.
https://doi.org/10.1073/pnas.1811516116
LAI welcomes new Post Doc members: Jorge Rodriguez Ramos, Claire Valotteau and Luca Piantanida!
Jorge Rodriguez Ramos joined the lab in November 2018, while Claire Valotteau and Luca Piantanida in January 2019. Jorge is working on the project “ Multi-scale mechanics of dynamic leukocyte adhesion ” and Claire is working on “Evolutionary mechanics of adhesion complexes” project both with Felix Rico. Luca Piantanida works with Ignacio Casuso on “Protein-induced lipids partitioning and cell mechanical properties influenced by Salmonella infection”. Welcome!
New equipment of Photolithography for Microfabrication and Microfluidics
A new Mask aligner MJB4 (Suss Microtec) was aquired via a shared action between LAI and Cinam and a financial support of Labex INFORM.
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