Yet another summer that ends with the graduation of a new PhD. Nicolas Garcia Seyda joined the lab as an engineer before deciding to pursue his PhD in the sunny city. He successfully defended his thesis entitled “Live imaging of leukocyte migration in controlled in vitro setups”. His presence in the lab is surely going to be missed, we wish him the best on his new adventures!
Geoffrey Delhaye has successfully defended his PhD thesis! After 3 years in sunny Marseille, he’s off to a new adventure befitting his free spirit. Our warmest congratulations to you, Geoffrey, and best of luck in your future pursuits!
LAI is happy to welcome the new batch of PhDs joining us this year.
Valentine Seveau will be using micro-fluidic techniques and micro-patterning technologies (PRIMO Alveole) to study the guidance of T cell lymphocytes mediated by integrins and cellular adhesion molecules on a substrate, also known as haptotaxis. She’ll be co-directed by Olivier Théodoly and Marie-Pierre Valignat.
Elodie Lafargue will be trying to characterize for the first time the rest structure of voltage-dependent channels at the molecular level as well as the dynamics of electrical signal transduction when opening or closing the transmembrane channel thanks to two novel breakthroughs in High-Speed Atomic Force Microscopy (HS-AFM) technology. Elodie will be supervised by Ignacio Casuso.
Rémy Torro and Lama Awada also joined us through the CENTURI PhD program. Rémy will be co-directed by Laurent Limozin at LAI and Kheya Sengupta at CINAM, he’ll be using reflection interference contrast microscopy (RICM) and deep learning-based techniques, as a systematic approach to perform 3D reconstructions of cell membranes at the interface with substrates. Lama on the other hand, is supervised by Philippe Robert at LAI and Pierre Milpied at CIML and she’ll be trying to characterize the nature of physical cues driving antibody affinity maturation in B cell immune responses using the laminar flow chamber in 2D while simultaneously integrating parallel analysis of transcriptome and antibody genes sequences at single-cell resolution.
Welcome everyone and we wish you a successful journey!
Dalia El Arawi started her LAI journey during COVID19 lockdown on the physical and computational aided design of bispecific antibodies for cancer immunotherapy under the supervision of Laurent Limozin. Her main objective will consist of testing bispecific antibodies using in vitro Antibody Dependent Cell Cytotoxicity mediated by NK cells employing TIRFM and RICM.
The EMBO workshop on Immunobiophysics in Les Houches has been postponed to 14–19 March 2021 with the same exceptional speaker list, and at the same amazing location!
Please stay tuned here and/or on the official EMBO Website/Letters for more information soon!
The organizing Committee is composed of:
Pierre-Henri Puech (Chair, LAI, Marseille), Katelyn Spillane (King’s College, London), Julien Husson (LadHyX, Polytechnique, Orsay), Laurent Limozin (LAI, Marseille), Jérémie Rossy (University of Konstanz, Kreuzlingen).
For more info: https://meetings.embo.org/event/20-immunobiophysics
& find us on Twitter @ImmunoBiophys
The lab is excited to have Arnauld Sergé joining its researchers staff. Arnauld is an associate professor in Biology and Physics at AMU. His research is centered on membrane dynamics using single-molecule microscopy and image analysis, with his current project focusing on « Dynamic videonanoscopy of immuno-cancer interactions ».
Thanks to the co-financing of S. Spicuglia (U1090) and a mutual request of the units to the region (U1067-U1090-U1097), the common cell culture platform of the building has recently acquired:
- a sorter BD FACSMelody: 3 lasers, 9 colors and single-cell module
- a BD LSRFortessa X20 cell analyser : 3 lasers, 14 colors
Lorenzo Villanueva joined the lab in March 2019 and he will work under supervision of Felix Rico on developing LabVIEW software as interface for High Speed AFM. Welcome Lorenzo!
Jorge Rodriguez Ramos joined the lab in November 2018, while Claire Valotteau and Luca Piantanida in January 2019. Jorge is working on the project “ Multi-scale mechanics of dynamic leukocyte adhesion ” and Claire is working on “Evolutionary mechanics of adhesion complexes” project both with Felix Rico. Luca Piantanida works with Ignacio Casuso on “Protein-induced lipids partitioning and cell mechanical properties influenced by Salmonella infection”. Welcome!