In recent work, Yong Jian Wang, Claire Valotteau, and Laurent Limozin managed to combine DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds. This work has been in done in collaboration with colleagues at CRCM and IBENS.
To know more about the work, don’t hesitate to reach out to Laurent Limozin or take a look at the article: https://www.cell.com/biophysj/fulltext/S0006-3495(23)00302-8
In press: CNRS
A medical doctor by training, Merlin decided to embark on a fundamental science journey in 2019 and hasn’t looked back since. Merlin did his Ph.D. under the supervision of Patrick Chames at CRCM and Laurent Limozin at LAI. He successfully defended his thesis which is entitled “Selection of nanobodies by a microfluidic mechanical approach for therapeutic purposes” in the presence of an expert jury consisting of Marie-Alix Poul, Charlie Gosse, and Hervé Nozach.
Merlin has already been employed by Immunocore in the UK where he’s utilizing his skills in a more applied setting. We wish him the best of luck, as well as a lot of Marvel content in his future!
We are pleased to announce that our very own Valentine Seveau received the Thesis Prize Award of the AMU ED 352 (Doctoral School of Physics) for the year 2022.
Under the guidance of Marie-Pierre Valignat and Olivier Theodoly, Valentine examined the behavior of cells in response to environmental cues during her thesis, titled “Quantitative study of cell guidance in controlled microenvironments: atypical cases of rheotaxis and adhesive haptotaxis”
We extend our congratulations to Valentine for the well-deserved recognition! Her achievement demonstrates the value of interdisciplinary research for advancing scientific knowledge.
In an inspiring fashion, the women of LAI showcased exceptional determination and strength by participating in La Marseillaise des Femmes race with the support of INSERM! After 3 months of intensive training, our very own athletes, or “Les Athlètes Improbables” as we like to call them achieved impressive results raising the bar high for the years to come. This event has sparked weekly running sessions the LAI members have been enjoying in the Calanques national park!
On Wednesday, 10th May, Mar successfully defended her Ph.D. project titled “Fast phenotyping of cell mechanics in the inflammatory response” in front of a jury composed of experts in the field: Nils Gauthier, Laura Picas, Jochen Guck, Jean-Luc Pellequer, Réjane Rua and Nathalie Pujol. We are delighted to share the news of her exceptional accomplishment and the invaluable contributions she has made to our lab’s research. Mar Eroles embarked on her Ph.D. journey as a student of the prestigious European ITN Phys2BioMed program to investigate the mechanics of monocytes and macrophages under hyperinflammatory conditions. Congratulations Mar and we can’t wait to see what you achieve next!
After a successful virtual conference in 2021, LAI members Pierre-Henri Peuch and Laurent Limozin took on the challenge of re-organizing the EMBO Workshop on ImmunoBiophysics: From fundamental physics to understanding the immune response. This time, the attendees had the chance to gather in the heart of Haute-Savoie at the Les Houches Physics School!
In addition, our Ph.D. students Marie Dessard, Jana El Husseiny, and Lama Awada presented posters on their projects while Rémy Torro gave a contributed talk for which he won the best talk prize!
For more information and updates on the upcoming organized talks: https://meetings.embo.org/event/23-immunobiophysics
We are happy to welcome Ramray Bhat, from IISc Bangalore this week! He is using both experimental and theoretical methods in order to understand how form changes or remains unchanged in physiological and pathological contexts. His research work focuses on cellular reorganization within the contexts of breast and ovarian cancer metastasis. By employing both experimental and theoretical approaches using simulations and bioinformatics, he aims to build experimentally motivated frameworks to understand their multiscale dynamics.
We are starting a collaborative project and are very excited to build new science together!
Ramray Bhat will give a talk entitled Unravelling interactive frameworks of cellular collectives in cancer migration on April, 3rd!
Leda just left LAI to start a post-doc in Pierre-François Lenne team at IBDM. We are already missing her and her good humor (as well as her Italian food!) and wish her the utmost success as she advances in her scientific career!
The EMBO Workshop: ImmunoBiophysics: From fundamental physics to understanding immune response is back with its newest edition! The workshop which is organized by our very own Pierre-Henri Puech and Laurent Limozin boasts an impressive list of speakers in the life sciences, biophysics, and mechanobiology fields.
The registration deadline is 5 March 2023. For more information: https://meetings.embo.org/event/20-immunobiophysics
LAI ends the year on a celebratory note with the successful thesis defense of Leda Lacaria! Leda joined LAI as a doc2amu student under the supervision of Felix Rico (LAI) and Loic Le Goff (Institut Fresnel), where she focused on the comparison between benign and malignant breast tumoral cells using atomic force microscopy in force mapping, traction force microscopy, spinning-disk fluorescence microscopy, and polarization-resolved fluorescence microscopy. Luckily, she’ll stay with us for a few months in 2023 before embarking on new scientific adventures so we can enjoy her presence for a while longer! 😄
Adhesion & Inflammation Lab 
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