A new patent “chitosan films and their use for the adhesion of microorganisms” was recently filed by Olivier THEODOLY from LAI, Tam MIGNOT (Laboratoire de chimie bactérienne, Marseille), Guillaume SUDRE and Laurent DAVID (Institut des matériaux polymères, Lyon).
Congratulations!
The project “Physical and computational aided design of bispecific antibodies for cancer immunotherapy” will be lead by LAI member Laurent Limozin in collaboration with P. Chames (CRCM, Marseille) and F. Piazza (CNRS, Orléans).
Congratulations!
LAI members Laurent Limozin, Anaïs Sadoun and Pierre-Henri Puech and former trainee Marie-Julie Dejardin recently published in Nanoletters (IF=12) on Lamellipod Reconstruction by Three-Dimensional Reflection Interference Contrast Nanoscopy (3D-RICN). You can read the paper here: https://pubs.acs.org/doi/ipdf/10.1021/acs.nanolett.8b03134.
Congratulations !
LAI will have two upcoming visiting students:
Eider Nunez Viadero who comes from the Biofisika institute in Bilbao (Spain).
She will stay for three months, till December 3rd, and do high speed AFM on a potassium channel with Arin Marchesi.
Clotilde Nodet, pharmacy students in her fifth year, will be doing a part-time six month elective until february 28th. She will work on effect of Natalizumab on lymphocyte adhesion and migration with Olivier Théodoly, Marie-Pierre Valignat and Philippe Robert in La Conception.
Welcome!
Long-time expertise of LAI (in collaboration with CINAM) in Reflection interference contrast microscopy have recently permitted a new advance to perform nanometer scale mapping of the cell lamellipod in vitro. Combining multicolor RICM with in silico reconstruction and using optical modeling, the topography of the upper and lower membrane of a lamellipod was reconstructed, as well as the refractive index mapped. These measurements were successfully compared with independent determinations using Atomic Force Microscopy or Quantitative Phase Imaging which both provide only a partial information.
https://doi.org/10.1021/acs.nanolett.8b03134
3D representations of basal membrane (left: seen from under) and of apical membrane (right : seen from top).
The book Nanoscale imaging is out. Here are the links to our two contributions:
Francesca Zuttion, Lorena Redondo-Morata, Arin Marchesi, Ignacio Casuso
Fidan Sumbul, Arin Marchesi, Hirohide Takahashi, Simon Scheuring, Felix Rico
Many congratulations!
LAI members Olivier Théodoly and Marie-Pierre Valignat have recently published an article in Journal of Fluid mechanics titled Topography of the lubrication film under a pancake droplet travelling in a Hele-Shaw cell.
Congratulations !
We had the pleasure to welcome Peta Clode, from Australia, on June 12th
for a visit of our lab and discussions around biophysical techniques, in
particular AFM. Peta came through EuroBioimaging Job Shadowing 2018
grant. It was a pleasure to exchange about imaging using various
techniques with her.
Her website :
https://research-repository.uwa.edu.au/en/persons/peta-clode
Farah Mustapha (Faculté de Sciences, rafic hariri, Lebanon) was selected by Doc2AMU program for a 3-year PhD funding on “Smart Interrogation of Mechanosensing in T cell Activation” with Pierre-Henri Puech and K.Sengupta (CINaM) as co-advisors. she will join in October the lab. Congratulations !
We welcome Aya Nassereddine, from Lebannon. After a master in immunology in Luminy, Aya has started her PhD under the direction of Kheya Sengupta (CINAM) and is now also coadvised by Laurent Limozin in LAI. She is preparing original transparent nanopatterned substrates and use them to study lymphocyte physiology with live microscopy.
Have a great time!
Adhesion & Inflammation Lab 
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