Cazaux S, Sadoun A, Pelicot-Biarnes M, Martinez M, Obeid S, Bongrand P, Limozin L, Puech P-H (2016) Synchronizing atomic force microscopy force mode and fluorescence microscopy in real time for immune cell stimulation and activation studies. Ultramicroscopy 160: 168-181.
Microfluidics, cell rheology and medical transfer
The long term effort to develop microfluidic tools to probe the rheological properties of circulating leukocytes has allowed getting new insight in the triggering mechanisms of the acute respiratory distress syndrome. This work, performed in a collaboration with Dr Forel and Pr Papazian from AP-HM has been published in Critical Care: “The leukocyte-stiffening property of plasma in early acute respiratory distress syndrome (ARDS) revealed by a microfluidic single-cell study: the role of cytokines and protection with antibodies”
Critical Care (2016) 20:8 DOI 10.1186/s13054-015-1157-5
Welcome Marie-Julie
Marie-Julie DEJARDIN is doing her Master 2 internship for 6 months, in the frame of the Nice University Imaging Program. She is financially supported by GDR MIV and will work on imaging APC lamellipods with combined AFM and interferometry under the direction of Pierre-Henri Puech and Laurent Limozin.
The project ‘Recrute’ has been awarded by ANR
This project intends to perform quantitative analysis of some essential steps of the leukocyte recruitment cascade using in vitro tools developed at LAI based on microfluidics and protein patterning. The in vitro approach will be based on and compared with in vivo models of T cell traffic in lymph node, T cell response to infection by Bordetella pertussis, and T cell properties of patients with multiple sclerosis. This project is a LAI collaboration with Alveole company (Luc Talini, Romuald Valy), Vincent Studer (IINS, Bordeaux), Claire Hivroz (Institut Curie, Paris) Marc Bajénoff and Jean-Pierre Gorvel (CIML), as well as Philippe Robert and Audrey Ricco (AP-HM).
External seminars, < 2016
2015
4/12/2015 Anna Labernardie (Barcelone, Spain)
27/11/2015 Giovanni Cappello (Liphys, Grenoble)
26/11/2015 Pierre Mangeol (IBDML, Marseille)
20/11/2015 Sébastien Sart (Ladhyx, Palaiseau)
19/11/2015 Jérôme Hottin (CBS, Montpellier)
16/11/2015 Andrey Zavialov (Turku, Finland)
6/11/2015 Martial Balland (Liphy, Grenoble)
16/10/2015 Cécile Bidan (Liphy, Grenoble)
29/9/2015 Demosthène Mitrossilis (Institut Curie, Paris)
2014
12/12/2014 Guillaume Gay (DAMCB, Marseille)
5/12/2014 Adrien Ducret (Indiana Univ., USA)
24/11/2014 Clemens Franz (Karlsruhe, Germany)
7/11/2014 Sylvain Gabriele (Mons, Belgium)
12/9/2014 Karine Anselme (IS2M, Mulhouse)
13/6/2014 Guillaume Voisinne (CIML, Marseille)
6/6/2014 Daniel Jost (ENS Lyon)
14/5/2014 Lena Svensson (Lund, Sweden)
12/5/2014 Cyrille Mionnet (Gand, Belgium)
2013
18/10/2013 Claire Hivroz (Institut Curie, Paris)
6/9/2013 Lionel Foret (LPS, Paris)
6/6/2013 Arnaud Millet (Institut Cochin, Paris)
24/5/2013 Julien Textoris (APHM, Marseille)
25/1/2013 Aurélien Dumètre (AMU, Marseille)
2012
14/12/2012 Salvatore Valitutti (Centre Physiologie, Toulouse)
15/10/2012 François Robin (Chicago, USA)
12/10/2012 Dimitri Missirlis (Heildeberg, Germany)
12/7/2012 Zhan Hua Silber Li (Beijing, China)
15/6/2012 Abdul Barakat (Ladhyx, Palaiseau)
23/3/2012 Delphine Muriaux, Cyrille Favard (CPBS, Montpellier)
2011
29/9/2011 Ulrich Blank (Inserm Bichat, Paris)
01/7/2011 Atef Asnacios (MSC, Paris)
10/6/2011 Catherine Even (LPS, Orsay)
13/5/2011 Patricia Veras, Washington Dos Santos (Salvador, Brasil)
18/3/2011 Marc Bajenoff (CIML, Marseille)
Labex Inform interdisciplinary lecture for PhD program
The LAI presented two teaching units during the Labex 1 week interdisciplinary teaching session for Starting PhD students (O Theodoly on rheology and cells mechanics, and Pierre-Henri Puech on image analysis).
A new post-doctoral fellow, Laurene Aoun!
Welcome to Laurene Aoun who joined our lab on November 1st 2015. Laurene is from Lebanon and she got her PhD in Biology, health and biotechnologies from the University of Toulouse. Her thesis was collaboration between LAAS and ITAV and evolved around the microfabrication of polymer microdevices in the purpose of understanding the mechanics of tumor growth using 3D cell models.
PhD Defense of Kamel
Mustapha Kamel Khelloufi defended his PhD thesis entitled: “Physics of mucociliary dynamics : device for studying the 3D cell migration : application to asthma and COPD” directed by Annie Viallat. Speciality Biophysics, Physics Doctoral School. The jury was also composed of: Jean-Marc Di Meglio (President), Pierre-Regis Burgel, Olivia Du Roure (Referees), Philippe Le Rouzic, Marc Jaeger, Isabelle Vachier, Pascal Chanez.
Link to the abstract: http://www.theses.fr/2015AIXM4060
Welcome Xuan Luo – the 2015 Labex Inform PhD fellow!
LAI is happy to welcome Xuan Luo to the lab as the 2015 Labex Inform PhD fellow. Xuan is a bioengineer previously working on bioprinted microfluidic organ-on-chip platform. During her PhD project, she will work on T cell migration and chemotaxis under the supervision of Dr. Olivier Théodoly. Welcome to the lab, Xuan!
Paulin Nègre defended his medical thesis!
Paulin Nègre PhD student and medical resident of LAI obtained his medical thesis on “Caractérisation quantitative de la migr
ation des leucocytes : applications médicales” (“Quantitative characterization of leukocytes migration : medical applications“). The jury (composed notably of Pierre Bongrand, Olivier Theodoly and Philippe Robert from LAI who wore very folkloric costumes for this occasion) was enthusiastic enough to deliver congratulations and suggest submission of the work for a thesis award!
Adhesion & Inflammation Lab 
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