External Seminar: Katelyn Spillane’s Insightful Talk on B Cell Activation

We are excited to highlight a key moment from our June 28th seminar. Katelyn Spillane from the Department of Life Sciences at Imperial College London delivered a fascinating presentation titled “Physical Regulation of B Cell Activation in the Immune Synapse.” She explored the intricate mechanisms behind B cell activation within the immune synapse.

Her talk captivated the audience, featuring an interactive Q&A session that encouraged deeper exploration and discussion of the latest research findings.

We extend our heartfelt thanks to Katelyn for her valuable contribution.

LAI celebrated its newest Dr !

On the 28th of June 2024, Lama Awada successfully defended her work titled “Imprint of mechanical forces on antibody affinity maturation in B cell immune responses“. This achievement was presented to a distinguished panel of experts in the field, including Katelyn Spillane, Paolo Pierobon, Rodolphe Jaffiol, and Kheya Sengupta. Lama’s journey began as a Centuri student, under the supervision of Philippe Robert from LAI and Pierre Milpied from CIML.

Her dedication and hard work have culminated in this significant accomplishment, marking a pivotal moment in her academic career. Best of luck in your future endeavors, Lama!

Laboratoire d’Informatique et Systèmes PhD Students Day !

We are pleased to share that Chandrasekar Subramani Narayana recently participated in the LIS (Laboratoire d’Informatique et Systèmes) PhD Students Day on June 7, 2024. He presented his work titled “Counting Phage: Decoding Antibody & Antigen Kinetics Behavior,” which focuses on the counting task in fluorescence microscopy images and count-guided localization using deep learning and computer vision.

The event offered a valuable opportunity for sharing scientific interests and knowledge while discovering the diverse range of topics being explored by other PhD students and research teams.

European Thymus Meeting Participation

We are excited to share Arnauld Sergé‘s participation in European Thymus in Porto, 27-31 May 2024

Arnauld presented a poster titled “Dynamics and Blockade of RANK/RANKL Interactions Between Leukemic and Thymic Epithelial Cells,” with contributions from Loriane Maillot, Martine Biarnes Pelicot, and Magali Irla from CIML.

T-cell acute lymphoblastic leukemias (T-ALL) are aggressive hematological cancers arising in the thymus from the malignant transformation of thymocytes. RANK and its ligand RANKL play a key role in thymic crosstalk. RANKL promotes thymic epithelial cell differentiation, sustaining the generation of a self-tolerant T-cell repertoire. The RANK/RANKL axis is a therapeutic target in oncology. However, its role in T-ALL remains unclear. RANKL is overexpressed during leukemogenesis. (i) we evaluate the dynamics of RANK/RANKL interactions, measured by single-molecule tracking. We evaluate the effects of an anti-RANKL antibody, a decoy receptor and the soluble form of RANKL. (ii) we assessthe therapeutic potential of an anti-RANKL antibody in T-ALL dissemination. Our aim is to shed light on the role of the RANK/RANKL axis in the emergence and dissemination of T-ALL.

17th International Toxoplasmosis Conference Participation

We are excited to announce that Aurélien Dumètre and Jana El Husseiny recently attended the 17th International Toxoplasmosis Conference in Berlin, Germany. This event covered various aspects of Toxoplasma research, ranging from molecular biology to clinical disease and epidemiology.

Before the main conference, they participated in the 3rd Environmental Toxoplasmosis Meeting, co-organized by Aurélien Dumètre and other experts in the field. This meeting focused on advancing the understanding of the environmental aspects and public health implications of Toxoplasmosis. Additionally, they attended a joint session with the ToxoDB workshop, which aimed to enhance participants skills and knowledge in using the ToxoDB database for research and data analysis.

Aurélien gave a talk at the workshop titled “Eimeria acervulina, a Promising Surrogate for the Study of Toxoplasma gondii Oocyst Inactivation.” Jana showcased her PhD project at both the workshop and the conference, delivering a talk at the workshop and presenting a turbo talk and a poster on her research titled “Unraveling Morphological and Biomechanical Responses to Harsh Environmental Conditions in Coccidian Oocysts.”

We are proud of their contributions and the recognition of their work at these significant scientific gatherings.

CENTURI – Turing Centre for Living Systems Scientific Day !

We are pleased to share that Ahmad Awada delivered an insightful presentation titled “Effects of Adhesion and Confinement on Leukocyte Migration” at the CENTURI – Turing Centre for Living Systems scientific day: Success Stories and New Horizons, held on May 30th at Jardins du Pharo.

The event was a remarkable gathering, bolstering the community spirit through networking and the sharing of ideas and future outlooks. It provided an excellent platform for researchers to connect, collaborate, and envision new horizons in scientific research.

Les Athlètes Improbables Return to La Marseillaise des Femmes 2024!

We are thrilled to announce that our lab team, “Les Athlètes Improbables,” has upheld their annual tradition by participating for the second time in La Marseillaise des Femmes 2024! Their continuous dedication and teamwork were on full display, demonstrating remarkable determination and spirit.

Congratulations to “Les Athlètes Improbables” for your outstanding effort and inspiration to us all!

GDR Approches Quantitatives du Vivant 2024 Conference Participation

We are excited to present our team’s key contributions to the GDR Approches Quantitatives du Vivant 2024 conference, held in Vogüé, Ardèche:

  • Ahmad Awada’s Poster Presentation: “Amoeboid Swimming is Propelled by Molecular Paddling in Lymphocytes”
  • Jana El Husseiny’s Poster Presentation: “Unraveling Morphological and Biomechanical Responses to Harsh Environmental Conditions in Coccidian Oocysts”
  • Valentine Seveau de Noray’s Talk: “Reverse Adhesive Haptotaxis: Cell Migration Towards Low Adhesion”

We extend our gratitude to the conference organizers for a stimulating and inspiring event. We look forward to continuing our research and sharing our findings with the scientific community.

LAI at Pint of Science 2024!

On May 14th, Olivier Theodoly and Ahmad Awada participated in this year’s Pint of Science festival. They captivated a public audience by discussing their research on immune cell migration and the intriguing laws that govern cell displacement. Loriane Maillot and Lama Awada also played crucial roles as event managers. The event was marked by vibrant interactions with the audience, showcasing the importance of scientific outreach and public engagement.

For more information about the festival, you can visit Pint of Science.

Chinese Edition of “Essentials of Soft Matter Science”!

We are thrilled to announce that the acclaimed book “Essentials of Soft Matter Science,” co-authored by Pierre-Henri Puech is now available in Chinese. This comprehensive guide covers key topics in soft matter physics, making it accessible to a wider audience. Ideal for students and researchers in physics, biology, chemistry, and engineering, this translation ensures more people can benefit from its insightful content.

Discover more about the book: https://www.cip.com.cn/Book/Index/78690