Les Athlètes Improbables Return to La Marseillaise des Femmes 2024!

We are thrilled to announce that our lab team, “Les Athlètes Improbables,” has upheld their annual tradition by participating for the second time in La Marseillaise des Femmes 2024! Their continuous dedication and teamwork were on full display, demonstrating remarkable determination and spirit.

Congratulations to “Les Athlètes Improbables” for your outstanding effort and inspiration to us all!

GDR Approches Quantitatives du Vivant 2024 Conference Participation

We are excited to present our team’s key contributions to the GDR Approches Quantitatives du Vivant 2024 conference, held in Vogüé, Ardèche:

  • Ahmad Awada’s Poster Presentation: “Amoeboid Swimming is Propelled by Molecular Paddling in Lymphocytes”
  • Jana El Husseiny’s Poster Presentation: “Unraveling Morphological and Biomechanical Responses to Harsh Environmental Conditions in Coccidian Oocysts”
  • Valentine Seveau de Noray’s Talk: “Reverse Adhesive Haptotaxis: Cell Migration Towards Low Adhesion”

We extend our gratitude to the conference organizers for a stimulating and inspiring event. We look forward to continuing our research and sharing our findings with the scientific community.

LAI at Pint of Science 2024!

On May 14th, Olivier Theodoly and Ahmad Awada participated in this year’s Pint of Science festival. They captivated a public audience by discussing their research on immune cell migration and the intriguing laws that govern cell displacement. Loriane Maillot and Lama Awada also played crucial roles as event managers. The event was marked by vibrant interactions with the audience, showcasing the importance of scientific outreach and public engagement.

For more information about the festival, you can visit Pint of Science.

Chinese Edition of “Essentials of Soft Matter Science”!

We are thrilled to announce that the acclaimed book “Essentials of Soft Matter Science,” co-authored by Pierre-Henri Puech is now available in Chinese. This comprehensive guide covers key topics in soft matter physics, making it accessible to a wider audience. Ideal for students and researchers in physics, biology, chemistry, and engineering, this translation ensures more people can benefit from its insightful content.

Discover more about the book: https://www.cip.com.cn/Book/Index/78690

LAI celebrated its newest Dr

On the 4th of April 2024, Rémy Torro, Ph.D. successfully defended his work titled “High throughput analysis of dynamic single cell interactions imaged by multimodal optical microscopy” in front of a jury composed of experts in the field, Alice Nicolas, David Rousseau, Daniel Sage, Loïc Dupré under the supervision of Laurent Limozin and Kheya sengupta. His work focused on develloping a software called Celldetective to describe complex cell interactions from multimodal microscopy images, leveraging recent AI techniques and applying it to test cell engagers for immunotherapy in cell-surface and cell-cell interaction assays.

Celldetective is now available and free to use on GitHub: https://lnkd.in/dGpj_UUx

Best of luck, Remy!

remy'defense

In association with CENTURI – Turing Centre for Living Systems

A new article on AI Tools for Immunofluorescence-Based Diagnostics

We are excited to share our latest research published in the International Journal of Molecular Sciences: “Comparison of the Capacity of Several Machine Learning Tools to Assist Immunofluorescence-Based Detection of Anti-Neutrophil Cytoplasmic Antibodies.”

This work was conducted in collaboration with Daniel Bertin and Nathalie Bardin, both members of the Immunology Laboratory of Marseille Hospitals, and Pierre Bongrand from LAI.

This study addresses a current challenge of using artificial intelligence to perform biomedical tasks without any human intervention, which might result in lower cost, increased availability and increased rapidity. Here, we compared the capacity of several widely available machine learning tools to analyze microscopic images in order to diagnose some autoimmunity diseases. The paper described preliminary results obtained with a dataset of 1,733 cell images.

For more information, visit the publication: https://doi.org/10.3390/ijms25063270.

Transforming Cell Assays: Bridging Science and Hospital Needs

Annual scientific day of Aix-Marseille University Imaging Institute took place February 23rd. Laureates of the 2023 call for interdisciplinary projects presented the progress of the past year of their respective projects. Among them, a collaborative project gathering Julien Lumeau, Fabien Lemarchand, Antonin Moreau from Fresnel Institute in Marseilles and Marie-Pierre Valignat, Olivier Theodoly and Philippe Robert from LAI was presented. It focuses on coupling micropatterned cellular assays from LAI to anti-reflexive surfaces produced by Fresnel Institute to detect protein secretion by cells, to obtain marker-less, manipulation-less and real-time assays adapted to routine hospital use.

LAI celebrates Marc Karnat’s thesis (Visiting PhD Student from CPT)

Marc did his Ph.D. under the supervision of Jean-Francois Rupprecht at CPT (kindly hosted at LAI) and funded by CENTURI. On monday, 18th December, he successfully defended his thesis which is entitled “Inferring the rheology of cellular materials through dedicated deep learning tools” in front of an expert jury consisting of Romain Levayer, Hervé Turlier, Hélène Delanoë-Ayari, Bianca Habermann, Thierry Artières and Sham Tlili.

Luckily, he’ll stay with us for a few months in 2024 to finish his project and we wish him the best of luck in his future. Again, Congratulations Marc for your incredible work !!

Christmas Festivities !

This December, the LAI team celebrated the holiday season in a special and memorable way. Members of the lab from around the world organized an international feast to highlight the varied culinary traditions of our team. It was a day full with laughter and a variety of flavors, representing our collective journey through a great year. Here’s to the memories we’ve made and the thrilling adventures that await us!