LAI celebrated its newest Dr

dupuyflorian News, PhD defense

On the 4th of April 2024, Rémy Torro, Ph.D. successfully defended his work titled “High throughput analysis of dynamic single cell interactions imaged by multimodal optical microscopy” in front of a jury composed of experts in the field, Alice Nicolas, David Rousseau, Daniel Sage, Loïc Dupré under the supervision of Laurent Limozin and Kheya sengupta. His work focused on develloping a software called Celldetective to describe complex cell interactions from multimodal microscopy images, leveraging recent AI techniques and applying it to test cell engagers for immunotherapy in cell-surface and cell-cell interaction assays.

Celldetective is now available and free to use on GitHub: https://lnkd.in/dGpj_UUx

Best of luck, Remy!

remy'defense

In association with CENTURI – Turing Centre for Living Systems

A new article on AI Tools for Immunofluorescence-Based Diagnostics

janaelhusseiny Article, News

We are excited to share our latest research published in the International Journal of Molecular Sciences: “Comparison of the Capacity of Several Machine Learning Tools to Assist Immunofluorescence-Based Detection of Anti-Neutrophil Cytoplasmic Antibodies.”

This work was conducted in collaboration with Daniel Bertin and Nathalie Bardin, both members of the Immunology Laboratory of Marseille Hospitals, and Pierre Bongrand from LAI.

This study addresses a current challenge of using artificial intelligence to perform biomedical tasks without any human intervention, which might result in lower cost, increased availability and increased rapidity. Here, we compared the capacity of several widely available machine learning tools to analyze microscopic images in order to diagnose some autoimmunity diseases. The paper described preliminary results obtained with a dataset of 1,733 cell images.

For more information, visit the publication: https://doi.org/10.3390/ijms25063270.

Transforming Cell Assays: Bridging Science and Hospital Needs

janaelhusseiny News

Annual scientific day of Aix-Marseille University Imaging Institute took place February 23rd. Laureates of the 2023 call for interdisciplinary projects presented the progress of the past year of their respective projects. Among them, a collaborative project gathering Julien Lumeau, Fabien Lemarchand, Antonin Moreau from Fresnel Institute in Marseilles and Marie-Pierre Valignat, Olivier Theodoly and Philippe Robert from LAI was presented. It focuses on coupling micropatterned cellular assays from LAI to anti-reflexive surfaces produced by Fresnel Institute to detect protein secretion by cells, to obtain marker-less, manipulation-less and real-time assays adapted to routine hospital use.

LAI celebrates Marc Karnat’s thesis (Visiting PhD Student from CPT)

dupuyflorian PhD defense

Marc did his Ph.D. under the supervision of Jean-Francois Rupprecht at CPT (kindly hosted at LAI) and funded by CENTURI. On monday, 18th December, he successfully defended his thesis which is entitled “Inferring the rheology of cellular materials through dedicated deep learning tools” in front of an expert jury consisting of Romain Levayer, Hervé Turlier, Hélène Delanoë-Ayari, Bianca Habermann, Thierry Artières and Sham Tlili.

Luckily, he’ll stay with us for a few months in 2024 to finish his project and we wish him the best of luck in his future. Again, Congratulations Marc for your incredible work !!

Christmas Festivities !

janaelhusseiny Lab life

This December, the LAI team celebrated the holiday season in a special and memorable way. Members of the lab from around the world organized an international feast to highlight the varied culinary traditions of our team. It was a day full with laughter and a variety of flavors, representing our collective journey through a great year. Here’s to the memories we’ve made and the thrilling adventures that await us!

LAI celebrates Achyuth Acharya’s thesis!

janaelhusseiny PhD defense

On the 11th of December, Achyuth Acharya successfully defend his work titled ‘Multiscale Characterization of Human Muscle Differentiation in vitro and the Influence of Mechanical Stimuli‘. The defense took place in front of a distinguished jury comprising experts in the field: Edgar Gomes, Delphine Duprez, Sylvain Gabrielle, and Sophie Chauvet.

Achyuth began his journey with IBDM and LAI as a Centuri student under the guidance of Frank Schnorrer from IBDM and Olivier Theodoly from LAI. He has now advanced to the next stage of his academic journey. He will be continuing his impactful project as a post-doc at IBDM, and we extend our heartfelt congratulations and best wishes to him.

Best of luck, Achyuth!

Congratulations Martine Biarnes Pelicot (our amazing engineer) for your contribution to the book “Etonnante physique” published by CNRS !!

dupuyflorian News

We are delighted to inform you that our engineer, Martine Biarnes Pelicot, has contributed to the book “Etonnante physique” published by CNRS. In her article, Martine explains how genetic engineering enables her to create tailor-made tools for studying the biophysics of immune cells.

This book brings together 70 contributions from physicists who have recently been awarded a CNRS medal. The book offers a captivating exploration of the many areas covered by this surprising discipline. It is designed to be accessible to all those who are curious about science.

We invite you to discover this fascinating book by following the link below: https://anneedelaphysique.cnrs.fr/ressource/etonnante-physique/”

CNRS IRP : Aaron Cruz-Ramirez is visiting LAI

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We are happy to welcome Aarón Cruz Ramírez, who runs the micro- and nano-fabrication facilities at the National Autonomous University of Mexico (UNAM).

During his visit, we had the pleasure of showcasing force-based techniques. Aarón also demonstrated his craftsmanship by creating nanoscribe surfaces, including a small surface featuring the LAI logo. To top it off, he shared valuable insights into his impressive work with our lab.

Valentine Seveau de Noray wins prestigious “Accessit du Prix Daniel Guinier” from SFP for her outsanding research!

janaelhusseiny News

We are delighted to share the remarkable achievement of Valentine Seveau de Noray, who has been honored with the “Accessit au prix Daniel Guinier” for the year 2022. This prestigious award is presented annually by the French Physical Society (SFP) to young physicists for their exceptional research during their doctoral studies.

Valentine’s dedication and innovative contributions to the field have earned her a second prize, a testament to her unwavering commitment to advancing scientific knowledge. Valentine finished her thesis “Quantitative study of cell guidance in controlled microenvironments: atypical cases of rheotaxis and adhesive haptotaxis” under the guidance of Olivier Theodoly and Marie-Pierre Valignat.

Congratulations, Valentine!

For more details on Valentine’s research and the award, please visit the link below: http://sfpnet.fr/baptiste-bienvenu-et-valentine-seveau-de-noray-accessits-aux-grands-prix-de-these-2022-de-la-sfp