LAI at Pint of Science 2024!

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On May 14th, Olivier Theodoly and Ahmad Awada participated in this year’s Pint of Science festival. They captivated a public audience by discussing their research on immune cell migration and the intriguing laws that govern cell displacement. Loriane Maillot and Lama Awada also played crucial roles as event managers. The event was marked by vibrant interactions with the audience, showcasing the importance of scientific outreach and public engagement.

For more information about the festival, you can visit Pint of Science.

Chinese Edition of “Essentials of Soft Matter Science”!

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We are thrilled to announce that the acclaimed book “Essentials of Soft Matter Science,” co-authored by Pierre-Henri Puech is now available in Chinese. This comprehensive guide covers key topics in soft matter physics, making it accessible to a wider audience. Ideal for students and researchers in physics, biology, chemistry, and engineering, this translation ensures more people can benefit from its insightful content.

Discover more about the book: https://www.cip.com.cn/Book/Index/78690

LAI celebrated its newest Dr

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On the 4th of April 2024, Rémy Torro, Ph.D. successfully defended his work titled “High throughput analysis of dynamic single cell interactions imaged by multimodal optical microscopy” in front of a jury composed of experts in the field, Alice Nicolas, David Rousseau, Daniel Sage, Loïc Dupré under the supervision of Laurent Limozin and Kheya sengupta. His work focused on develloping a software called Celldetective to describe complex cell interactions from multimodal microscopy images, leveraging recent AI techniques and applying it to test cell engagers for immunotherapy in cell-surface and cell-cell interaction assays.

Celldetective is now available and free to use on GitHub: https://lnkd.in/dGpj_UUx

Best of luck, Remy!

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In association with CENTURI – Turing Centre for Living Systems

A new article on AI Tools for Immunofluorescence-Based Diagnostics

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We are excited to share our latest research published in the International Journal of Molecular Sciences: “Comparison of the Capacity of Several Machine Learning Tools to Assist Immunofluorescence-Based Detection of Anti-Neutrophil Cytoplasmic Antibodies.”

This work was conducted in collaboration with Daniel Bertin and Nathalie Bardin, both members of the Immunology Laboratory of Marseille Hospitals, and Pierre Bongrand from LAI.

This study addresses a current challenge of using artificial intelligence to perform biomedical tasks without any human intervention, which might result in lower cost, increased availability and increased rapidity. Here, we compared the capacity of several widely available machine learning tools to analyze microscopic images in order to diagnose some autoimmunity diseases. The paper described preliminary results obtained with a dataset of 1,733 cell images.

For more information, visit the publication: https://doi.org/10.3390/ijms25063270.

Transforming Cell Assays: Bridging Science and Hospital Needs

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Annual scientific day of Aix-Marseille University Imaging Institute took place February 23rd. Laureates of the 2023 call for interdisciplinary projects presented the progress of the past year of their respective projects. Among them, a collaborative project gathering Julien Lumeau, Fabien Lemarchand, Antonin Moreau from Fresnel Institute in Marseilles and Marie-Pierre Valignat, Olivier Theodoly and Philippe Robert from LAI was presented. It focuses on coupling micropatterned cellular assays from LAI to anti-reflexive surfaces produced by Fresnel Institute to detect protein secretion by cells, to obtain marker-less, manipulation-less and real-time assays adapted to routine hospital use.

LAI celebrates Marc Karnat’s thesis (Visiting PhD Student from CPT)

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Marc did his Ph.D. under the supervision of Jean-Francois Rupprecht at CPT (kindly hosted at LAI) and funded by CENTURI. On monday, 18th December, he successfully defended his thesis which is entitled “Inferring the rheology of cellular materials through dedicated deep learning tools” in front of an expert jury consisting of Romain Levayer, Hervé Turlier, Hélène Delanoë-Ayari, Bianca Habermann, Thierry Artières and Sham Tlili.

Luckily, he’ll stay with us for a few months in 2024 to finish his project and we wish him the best of luck in his future. Again, Congratulations Marc for your incredible work !!

Christmas Festivities !

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This December, the LAI team celebrated the holiday season in a special and memorable way. Members of the lab from around the world organized an international feast to highlight the varied culinary traditions of our team. It was a day full with laughter and a variety of flavors, representing our collective journey through a great year. Here’s to the memories we’ve made and the thrilling adventures that await us!

LAI celebrates Achyuth Acharya’s thesis!

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On the 11th of December, Achyuth Acharya successfully defend his work titled ‘Multiscale Characterization of Human Muscle Differentiation in vitro and the Influence of Mechanical Stimuli‘. The defense took place in front of a distinguished jury comprising experts in the field: Edgar Gomes, Delphine Duprez, Sylvain Gabrielle, and Sophie Chauvet.

Achyuth began his journey with IBDM and LAI as a Centuri student under the guidance of Frank Schnorrer from IBDM and Olivier Theodoly from LAI. He has now advanced to the next stage of his academic journey. He will be continuing his impactful project as a post-doc at IBDM, and we extend our heartfelt congratulations and best wishes to him.

Best of luck, Achyuth!

Congratulations Martine Biarnes Pelicot (our amazing engineer) for your contribution to the book “Etonnante physique” published by CNRS !!

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We are delighted to inform you that our engineer, Martine Biarnes Pelicot, has contributed to the book “Etonnante physique” published by CNRS. In her article, Martine explains how genetic engineering enables her to create tailor-made tools for studying the biophysics of immune cells.

This book brings together 70 contributions from physicists who have recently been awarded a CNRS medal. The book offers a captivating exploration of the many areas covered by this surprising discipline. It is designed to be accessible to all those who are curious about science.

We invite you to discover this fascinating book by following the link below: https://anneedelaphysique.cnrs.fr/ressource/etonnante-physique/”